Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 5/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7782054 | 0.83 | ESR2 (0.49) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL1885756 | 0.83 | ESR2 (0.49) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL1905793 | 0.82 | ESR2 (0.45) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL7786915 | 0.82 | ESR2 (0.45) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL7787597 | 0.82 | ESR2 (0.45) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL7791096 | 0.81 | ESR2 (0.48) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL1892357 | 0.81 | ESR2 (0.48) | ESR2ESR1GRM2MEN1ALOX15 | |
| SCHEMBL10529811 | 0.81 | ESR2 (0.54) | ESR2ESR1MEN1ALOX15TSHR | |
| SCHEMBL1891390 | 0.80 | ESR2 (0.46) | ESR2ESR1GRM2HSD17B10 | |
| SCHEMBL7786874 | 0.80 | ESR2 (0.46) | ESR2ESR1GRM2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217287-B1 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | claimed |
| EP-0217287-A2 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1987-04-08 | — | — | EP | claimed |
| EP-0217287-B1 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0217287-A2 | [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxy]ethanimidamides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts | MERCK & CO. INC. (US) | 1987-04-08 | — | — | EP | disclosed |
| US-4604396-A | TREATMENT OF GREY MATTER EDEMAS | MERCK & CO., INC. (US) | 1986-08-05 | — | — | US | disclosed |