Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814053 | 1.00 | TYR (0.49) | TYRKAT8PPARACYP1A2CYP2C9 | |
| SCHEMBL9814051 | 1.00 | TYR (0.49) | TYRKAT8PPARACYP1A2CYP2C9 | |
| SCHEMBL9121697 | 0.98 | CYP1A2 (0.47) | TYRKAT8PPARACYP1A2CYP2C9 | |
| SCHEMBL10975179 | 0.93 | CYP1A2 (0.48) | PPARACYP1A2CYP2C9ALDH1A1CYP2D6 | |
| SCHEMBL8968774 | 0.89 | TYR (0.50) | TYRKAT8PPARAPPARGALOX5 | |
| SCHEMBL30736074 | 0.86 | CYP1A2 (0.50) | PPARACYP1A2CYP2C9ALDH1A1CYP2D6 | |
| SCHEMBL480388 | 0.86 | CYP1A2 (0.50) | PPARACYP1A2CYP2C9ALDH1A1CYP2D6 | |
| SCHEMBL27375877 | 0.84 | TYR (0.45) | TYRKAT8PPARAALDH1A1LMNA | |
| SCHEMBL7041417 | 0.82 | CYP1A2 (0.47) | PPARACYP1A2CYP2C9ALDH1A1CYP2D6 | |
| SCHEMBL31402502 | 0.82 | KAT8 (0.47) | TYRKAT8PPARAPPARGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295882-B1 | PROCESS FOR INTERMEDIATES TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0295882-A1 | Process for intermediates to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| US-4777299-A | Process for leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-11 | — | — | US | disclosed |