Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GGT1 | P19440 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708950 | 0.84 | LMNA (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9638920 | 0.83 | CTNNB1 (0.58) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL54071 | 0.82 | SMN1; SMN2 (0.68) | LMNAKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29432808 | 0.82 | SMN1; SMN2 (0.68) | LMNAKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL29679671 | 0.81 | CTNNB1 (0.67) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL3179214 | 0.81 | CTNNB1 (0.67) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| Ethylene Glycol SCHEMBL29185194 | 0.81 | LMNA (0.58) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL16976609 | 0.80 | LMNA (0.56) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11050544 | 0.80 | KDM4E (0.74) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1004350 | 0.80 | KMT2A (0.59) | LMNAKDM4ESMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295883-B1 | PROCESS FOR INTERMEDIATES TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0295883-A1 | Process for intermediates to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| US-4777298-A | Process for intermediates to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-11 | — | — | US | disclosed |