Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814536 | 1.00 | CYP1A2 (0.56) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL9814716 | 0.89 | CYP1A2 (0.51) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| E-5110 SCHEMBL5323330 | 0.86 | CYP1A2 (0.59) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| E-5110 SCHEMBL677921 | 0.86 | CYP1A2 (0.59) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| E-5110 SCHEMBL1164013 | 0.86 | CYP1A2 (0.59) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL10623812 | 0.81 | CYP1A2 (0.51) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL10623819 | 0.81 | CYP1A2 (0.51) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL9814650 | 0.81 | CYP1A2 (0.59) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL9814646 | 0.81 | CYP1A2 (0.59) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8910255 | 0.79 | CYP1A2 (0.64) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204964-B1 | 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |