Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9806651 | 1.00 | TDP1 (0.47) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL11017606 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL197143 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL9803493 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL9803750 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL1450045 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL10603686 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL10603455 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL17008412 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 | |
| Hydrochloric Acid SCHEMBL19460486 | 0.97 | CYP3A4 (0.45) | TDP1CYP3A4KDM4EGAAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336216-B1 | PROCESS FOR THE PREPARATION OF MONOCARBOXYLIC ACID ANHYDRIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-12-27 | — | — | EP | disclosed |
| EP-0332969-B1 | PROCESS FOR THE PREPARATION OF MONOCARBOXYLIC-ACID ANHYDRIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |
| EP-0336215-B1 | SUPPORTED CATALYST FOR THE PREPARATION OF ANHYDRIDES OF MONOCARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-15 | — | — | EP | disclosed |
| US-4965234-A | Supported catalyst for the preparation of monocarboxylic anhydrides | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-23 | — | — | US | disclosed |
| US-4959498-A | Process for the preparation of monocarboxylic anhydrides | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-25 | — | — | US | disclosed |
| US-4952727-A | Process for the preparation of monocarboxylic anhydrides | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |
| EP-0336215-A1 | Supported catalyst for the preparation of anhydrides of monocarboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-11 | — | — | EP | disclosed |
| EP-0336216-A1 | Process for the preparation of monocarboxylic acid anhydrides | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-10-11 | — | — | EP | disclosed |