Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.53 |
| ▸ | PPARG | P37231 | 3/20 | 0.53 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | F7 | P08709 | 3/20 | 0.42 |
| ▸ | F3 | P13726 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9816169 | 1.00 | PPARA (0.53) | PPARAPPARGSOAT2SOAT1EPHX2 | |
| SCHEMBL17055396 | 0.99 | PPARA (0.54) | PPARAPPARGSOAT2SOAT1EPHX2 | |
| SCHEMBL17055397 | 0.99 | PPARA (0.54) | PPARAPPARGSOAT2SOAT1EPHX2 | |
| SCHEMBL28826330 | 0.90 | PPARG (0.48) | PPARAPPARGFAAHALDH1A1LMNA | |
| SCHEMBL2238586 | 0.83 | PPARA (0.52) | PPARAPPARGSOAT2SOAT1EPHX2 | |
| SCHEMBL18140030 | 0.82 | PPARG (0.44) | PPARAPPARGFAAHALDH1A1LMNA | |
| SCHEMBL18139546 | 0.82 | PPARG (0.44) | PPARAPPARGFAAHALDH1A1LMNA | |
| SCHEMBL18139598 | 0.82 | PPARG (0.44) | PPARAPPARGFAAHALDH1A1LMNA | |
| SCHEMBL18140944 | 0.82 | PPARG (0.44) | PPARAPPARGFAAHALDH1A1LMNA | |
| SCHEMBL18141571 | 0.82 | PPARG (0.44) | PPARAPPARGFAAHALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257786-B1 | DOSAGE FORM FOR DELIVERING ACID SENSITIVE BENEFICIAL AGENT | ALZA CORPORATION (US) | 1991-08-28 | — | — | EP | disclosed |
| US-4743248-A | Dosage form for delivering acid sensitive beneficial agent | ALZA CORPORATION (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0257786-A2 | Dosage form for delivering acid sensitive beneficial agent | ALZA CORPORATION (US) | 1988-03-02 | — | — | EP | disclosed |