Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RARB | P10826 | 5/20 | 0.34 |
| ▸ | RARG | P13631 | 5/20 | 0.34 |
| ▸ | RARA | P10276 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9817657 | 0.99 | CYP26A1 (0.36) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817740 | 0.97 | RXRA (0.37) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817761 | 0.94 | RXRA (0.38) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817703 | 0.91 | CYP26A1 (0.40) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL8662753 | 0.90 | FDFT1 (0.36) | FDFT1MAPTLIPEPPARGPPARA | |
| SCHEMBL9817799 | 0.87 | RARB (0.42) | RXRACYP26A1CYP26B1HNF4AMAPT | |
| SCHEMBL9817887 | 0.86 | RXRA (0.41) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817643 | 0.86 | CYP26A1 (0.35) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817861 | 0.85 | CYP26A1 (0.35) | RXRACYP26A1CYP26B1FDFT1HNF4A | |
| SCHEMBL9817709 | 0.85 | CYP26A1 (0.36) | RXRACYP26A1CYP26B1FDFT1HNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | disclosed |