Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818861 | 1.00 | AKR1B1 (0.48) | AKR1B1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL9818971 | 0.89 | FFAR1 (0.46) | AKR1B1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL9818968 | 0.89 | FFAR1 (0.46) | AKR1B1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL9818767 | 0.81 | AKR1B1 (0.45) | AKR1B1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL9818765 | 0.81 | AKR1B1 (0.45) | AKR1B1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL27347334 | 0.80 | FFAR1 (0.60) | FFAR1PPARGPPARD | |
| SCHEMBL27347336 | 0.80 | FFAR1 (0.60) | FFAR1PPARGPPARD | |
| SCHEMBL27347333 | 0.80 | FFAR1 (0.60) | FFAR1PPARGPPARD | |
| SCHEMBL18643710 | 0.74 | CREBBP (0.44) | AKR1B1MAPTALDH1A1GAAKMT2A | |
| SCHEMBL14449327 | 0.74 | CREBBP (0.44) | AKR1B1MAPTALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |