Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 0.65 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819049 | 1.00 | MAOB (0.65) | MAOBPBRM1NPC1BRD4CREBBP | |
| SCHEMBL3683723 | 0.86 | PBRM1 (0.69) | MAOBPBRM1NPC1BRD4CREBBP | |
| SCHEMBL3681000 | 0.86 | PBRM1 (0.69) | MAOBPBRM1NPC1BRD4CREBBP | |
| SCHEMBL9818829 | 0.81 | PBRM1 (0.54) | MAOBPBRM1CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL9819102 | 0.81 | PBRM1 (0.77) | MAOBPBRM1CYP19A1CYP3A4 | |
| SCHEMBL9819050 | 0.81 | MAOB (0.63) | MAOBPBRM1 | |
| SCHEMBL9749344 | 0.81 | CYP19A1 (0.63) | MAOBPBRM1BRD4CREBBPCYP19A1 | |
| SCHEMBL9464541 | 0.79 | CYP19A1 (0.68) | MAOBCYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL11377137 | 0.79 | PBRM1 (0.58) | MAOBPBRM1NPC1BRD4CREBBP | |
| SCHEMBL22714605 | 0.78 | PBRM1 (0.50) | MAOBPBRM1NPC1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111518112-B | Bis-furanone pyran compound and preparation method and application thereof | 四川什邡市三高生化实业有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-111518112-A | Bis-furanone pyran compound and preparation method and application thereof | 朱翠萍 | 2020-08-11 | — | — | CN | claimed |
| CN-111518112-B | Bis-furanone pyran compound and preparation method and application thereof | 四川什邡市三高生化实业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-111518112-A | Bis-furanone pyran compound and preparation method and application thereof | 朱翠萍 | 2020-08-11 | — | — | CN | disclosed |
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |