SCHEMBL9749344

SCHEMBL9749344

CC1CC(=O)c2ccc(O)cc2O1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 9/20 0.63
TUBB4A P04350 1/20 0.63
TUBB P07437 1/20 0.63
YES1 P07947 1/20 0.63
TUBA3C P0DPH7 1/20 0.63
TUBA1B P68363 1/20 0.63
TUBA4A P68366 1/20 0.63
TUBB4B P68371 1/20 0.63
TUBB3 Q13509 1/20 0.63
TUBB2A Q13885 1/20 0.63
TUBB8 Q3ZCM7 1/20 0.63
TUBA3E Q6PEY2 1/20 0.63
TUBA1A Q71U36 1/20 0.63
ESR2 Q92731 1/20 0.63
TUBA1C Q9BQE3 1/20 0.63
TUBB6 Q9BUF5 1/20 0.63
TUBB2B Q9BVA1 1/20 0.63
TUBB1 Q9H4B7 1/20 0.63
MAOA P21397 2/20 0.61
MAOB P27338 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9819049 0.81 MAOB (0.65) CYP19A1MAOBPBRM1BRD4CREBBP
SCHEMBL9819043 0.81 MAOB (0.65) CYP19A1MAOBPBRM1BRD4CREBBP
SCHEMBL9819050 0.80 MAOB (0.63) MAOBPBRM1
SCHEMBL9819102 0.80 PBRM1 (0.77) CYP19A1TUBB4ATUBBYES1TUBA3C
SCHEMBL9818829 0.80 PBRM1 (0.54) CYP19A1TUBB4ATUBBYES1TUBA3C
SCHEMBL17973709 0.80 CYP19A1 (0.59) CYP19A1TUBB4ATUBBYES1TUBA3C
SCHEMBL22714605 0.80 PBRM1 (0.50) CYP19A1TUBB4ATUBBYES1TUBA3C
SCHEMBL27984356 0.80 TDP1 (0.61) CYP19A1TUBB4ATUBBYES1TUBA3C
Liquirtigenin SCHEMBL1071066 0.78 CYP19A1 (1.00) CYP19A1TUBB4ATUBBYES1TUBA3C
Liquirtigenin SCHEMBL30352791 0.78 CYP19A1 (1.00) CYP19A1TUBB4ATUBBYES1TUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4126835-B1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 EP disclosed
US-12516038-B2 Inhibitors of antigen presentation by HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-01-06 US disclosed
CN-110770211-B Alpha, beta unsaturated amide compound 协和麒麟株式会社 2023-09-19 CN disclosed
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2023-05-18 US disclosed
EP-4126835-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR Janssen Pharmaceutica NV (BE) 2023-02-08 EP disclosed
CN-108430972-B Alpha, beta-unsaturated amide compound 协和麒麟株式会社 2022-12-27 CN disclosed
US-11447471-B2 α,β-unsaturated amide compound KYOWA KIRIN CO., LTD. (JP) 2022-09-20 US disclosed
US-20220160676-A1 USE OF 3-O-SULFAMOYLOXY-7Beta-METHYL-D-HOMO-6-OXAESTRA-1,3,5(10),8(9)-TETRAEN-17A-ONE TO TREAT BREAST CANCER ILIASOVA, NATALIA (RU) 2022-05-26 US disclosed
US-11332455-B2 α,β-unsaturated amide compound KYOWA KIRIN CO., LTD. (JP) 2022-05-17 US disclosed
US-20210380551-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND KYOWA KIRIN CO., LTD. (JP) 2021-12-09 US disclosed
US-20210155612-A1 Alpha,Beta-UNSATURATED AMIDE COMPOUND KYOWA KIRIN CO., LTD. (JP) 2021-05-27 US disclosed
US-10787428-B2 α,β-unsaturated amide compound KYOWA KIRIN CO., LTD. (JP) 2020-09-29 US disclosed
EP-3712129-A1 ALPHA, BETA-UNSATURATED AMIDE COMPOUND Kyowa Kirin Co., Ltd. (JP) 2020-09-23 EP disclosed
CN-110770211-A α unsaturated amide compound 协和麒麟株式会社 2020-02-07 CN disclosed
US-20190010136-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-01-10 US disclosed
EP-3401309-A1 a, ß UNSATURATED AMIDE COMPOUND Kyowa Hakko Kirin Co., Ltd. (JP) 2018-11-14 EP disclosed
CN-108430972-A α, β unsaturated acyl amine compounds 协和发酵麒麟株式会社 2018-08-21 CN disclosed
WO-2014146553-A1 FLAVONOID DERIVATIVES AND USE THEREOF 江苏恩华药业股份有限公司 (CN) 2014-09-25 WO disclosed
EP-0230475-B1 NOVEL UREA DERIVATIVES, PROCESSES FOR PRODUCTION THEREOF AND HERBICIDE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1992-03-18 EP disclosed
US-4838924-A NONPHYTOTOXIC MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210155612-A1 Alpha,Beta-UNSATURATED AMIDE COMPOUND NR1H2, NR1H3, RXRA CYP19A1 474/4885TUBB4A 1772/4885TUBB 1583/4885
US-11447471-B2 α,β-unsaturated amide compound NR1H2, RXRA, RXRB CYP19A1 404/4885TUBB4A 1869/4885TUBB 1751/4885
US-10787428-B2 α,β-unsaturated amide compound NR1H2, NCOA1, NR0B1 CYP19A1 269/4885TUBB4A 2377/4885TUBB 2402/4885
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR HLA-DRB1, CD74, HLA-C CYP19A1 3518/4885TUBB4A 3889/4885TUBB 3077/4885
US-20220160676-A1 USE OF 3-O-SULFAMOYLOXY-7Beta-METHYL-D-HOMO-6-OXAESTRA-1,3,5(10),8(9)-TETRAEN-17A-ONE TO TREAT BREAST CANCER SULT1E1, BRCA1, CYP19A1 CYP19A1 3/4885TUBB4A 443/4885TUBB 435/4885
US-20210380551-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND NR1H2, NR1H3, NCOA1 CYP19A1 302/4885TUBB4A 2172/4885TUBB 2081/4885
US-11332455-B2 α,β-unsaturated amide compound NR1H2, NCOA1, NR0B1 CYP19A1 269/4885TUBB4A 2377/4885TUBB 2402/4885
US-20190010136-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND NR1H2, NR1H3, NCOA1 CYP19A1 302/4885TUBB4A 2172/4885TUBB 2081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.