Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.40 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985123 | 0.91 | JAK3 (0.41) | JAK3JAK2 | |
| SCHEMBL983558 | 0.89 | PDE4B (0.36) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL984962 | 0.89 | JAK3 (0.40) | JAK3JAK2 | |
| SCHEMBL985551 | 0.87 | JAK3 (0.41) | JAK3JAK2 | |
| SCHEMBL983088 | 0.85 | JAK3 (0.46) | JAK3JAK2 | |
| SCHEMBL984731 | 0.84 | JAK3 (0.45) | JAK3JAK2 | |
| SCHEMBL983194 | 0.82 | JAK3 (0.38) | JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL985238 | 0.82 | PDE4D (0.35) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL986677 | 0.82 | JAK2 (0.43) | JAK3JAK2 | |
| SCHEMBL981991 | 0.81 | DHODH (0.35) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | JAK3 1732/4885JAK2 1660/4885PDE4B 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.