Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.36 |
| ▸ | PDE4A | P27815 | 9/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982755 | 0.89 | KDM4C (0.39) | PDE4BPDE4DPDE4APDE4CKDM4C | |
| SCHEMBL981908 | 0.89 | JAK3 (0.40) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL985069 | 0.87 | KDM4C (0.38) | KDM4CCAMKK1CAMKK2KMOKDM5A | |
| SCHEMBL984995 | 0.87 | KDM4C (0.37) | KDM4CCAMKK1CAMKK2KMOKDM5A | |
| Hydrochloric Acid SCHEMBL985238 | 0.85 | PDE4D (0.35) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL983554 | 0.85 | KDM4C (0.39) | PDE4DKDM4CCAMKK1CAMKK2KMO | |
| SCHEMBL985692 | 0.83 | KDM5A (0.44) | KDM4CKMOKDM5A | |
| SCHEMBL981991 | 0.83 | DHODH (0.35) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL984263 | 0.82 | PDE4D (0.33) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL986385 | 0.82 | BRD4 (0.43) | KDM4CKMOKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | PDE4B 7/4885PDE4D 12/4885PDE4A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.