Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818966 | 0.87 | MCL1 (0.39) | SMN1; SMN2KMT2ATSHRMEN1POLB | |
| SCHEMBL9819197 | 0.80 | APP (0.40) | KMT2ATSHRKDM4EMEN1POLB | |
| SCHEMBL9819158 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2ANPSR1GAAHPGD | |
| SCHEMBL9819221 | 0.74 | TSHR (0.39) | SMN1; SMN2TSHRCYP1A2CYP2C19POLB | |
| SCHEMBL11670492 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2ANPSR1TSHRCYP1A2 | |
| SCHEMBL9819164 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2ANPSR1GAAHPGD | |
| SCHEMBL9819407 | 0.69 | SMN1; SMN2 (0.34) | SMN1; SMN2NPSR1GAAHPGDTSHR | |
| SCHEMBL4716499 | 0.67 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2ANPSR1TSHRCYP1A2 | |
| SCHEMBL11508791 | 0.66 | MCOLN3 (0.47) | SMN1; SMN2KMT2ANPSR1TSHRCYP1A2 | |
| SCHEMBL11688661 | 0.66 | MCOLN3 (0.47) | SMN1; SMN2KMT2ANPSR1TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312338-B1 | SULFAMOYL-2-BENZOFURANCARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-12-27 | — | — | EP | claimed |
| US-4918206-A | DIURETICS, HYPOTENSIVE AGENTS; SIDE EFFECT REDUCTION | SHIONOGI & CO., LTD. (JP) | 1990-04-17 | — | — | US | claimed |