Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819221 | 0.86 | TSHR (0.39) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9819197 | 0.74 | APP (0.40) | TSHRALDH1A1KDM4EAPPPOLB | |
| SCHEMBL9819399 | 0.72 | MAPT (0.37) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9818966 | 0.71 | MCL1 (0.39) | SMN1; SMN2TSHRALDH1A1L3MBTL1MAPT | |
| SCHEMBL9819224 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9819018 | 0.69 | ALDH1A1 (0.38) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL21798603 | 0.67 | GAA (0.46) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9819059 | 0.67 | GSTO1 (0.36) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL20501221 | 0.63 | POLB (0.43) | SMN1; SMN2TSHRALDH1A1HPGDMAPT | |
| SCHEMBL20449571 | 0.63 | GAA (0.43) | SMN1; SMN2TSHRCYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312338-B1 | SULFAMOYL-2-BENZOFURANCARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4918206-A | DIURETICS, HYPOTENSIVE AGENTS; SIDE EFFECT REDUCTION | SHIONOGI & CO., LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| EP-0312338-A1 | Sulfamoyl-2-benzofurancarboxylic acid derivatives, their preparation and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-04-19 | — | — | EP | disclosed |