Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6019844 | 0.84 | KDM4E (0.48) | CDK8MAPK14KMT2AKDM4EGAA | |
| SCHEMBL9819419 | 0.79 | KMT2A (0.60) | MAPK14KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11641269 | 0.77 | KDM4E (0.62) | KMT2AKDM4EGAAALDH1A1HPGD | |
| SCHEMBL11716685 | 0.75 | SMN1; SMN2 (0.57) | KMT2AKDM4EGAAALDH1A1HPGD | |
| SCHEMBL8340991 | 0.74 | HDAC3 (0.48) | KMT2AGAAALDH1A1HPGDMAPT | |
| SCHEMBL13984133 | 0.73 | EPHX1 (0.58) | KMT2AKDM4EGAAALDH1A1HPGD | |
| SCHEMBL6321405 | 0.73 | MAPT (0.62) | KDM4EGAAALDH1A1HPGDMAPT | |
| SCHEMBL15975493 | 0.71 | EPHX1 (0.56) | KMT2AKDM4EGAAALDH1A1HPGD | |
| SCHEMBL6019838 | 0.71 | KMT2A (0.58) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL8338952 | 0.70 | ALDH1A1 (0.46) | KMT2AKDM4EGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162669-B1 | ANTICONVULSIVE COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4588729-A | Treating convulsions with dihydrouracil derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-05-13 | — | — | US | disclosed |
| EP-0162669-A2 | Anticonvulsive compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-11-27 | — | — | EP | disclosed |