Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819421 | 0.95 | CYP3A4 (0.58) | CYP3A4CYP2C19CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL9819475 | 0.83 | POLB (0.43) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9819516 | 0.83 | LMNA (0.44) | MAPTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL9819537 | 0.82 | GAA (0.44) | CYP2C19CYP1A2ALDH1A1CYP2D6POLB | |
| SCHEMBL9819472 | 0.80 | HDAC1 (0.43) | KDM4EALDH1A1HPGDPOLBHDAC3 | |
| SCHEMBL9819544 | 0.79 | POLB (0.40) | ALDH1A1POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL9819511 | 0.78 | POLB (0.49) | CYP3A4CYP2C19CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL9819468 | 0.78 | LMNA (0.47) | CYP2C19CYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL9819528 | 0.78 | POLB (0.47) | SMN1; SMN2ALDH1A1HPGDPOLBHDAC3 | |
| SCHEMBL23430664 | 0.76 | HPGD (0.58) | SMN1; SMN2KDM4EALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0317588-B1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4985428-A | Isoxazoles with nootropic activity | ZAMBON GROUP S.P.A. (IT) | 1991-01-15 | — | — | US | disclosed |
| EP-0317588-A1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY. | ZAMBON SPA (IT) | 1989-05-31 | — | — | EP | disclosed |
| WO-1988009330-A1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1988-12-01 | — | — | WO | disclosed |