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Cortisone Acetate

Cortisone Acetate

SCHEMBL9819561

CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3C(=O)C[C@@]21C.CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Cortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 3/20 1.00
▸ FNTA P49354 5/20 1.00
▸ FNTB P49356 5/20 1.00
▸ TSHR P16473 3/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ AR P10275 2/20 1.00
▸ BLM P54132 2/20 1.00
▸ MEN1 O00255 1/20 1.00
▸ HSD17B10 Q99714 5/20 0.78
▸ SERPINA6 P08185 5/20 0.78
▸ CYP3A4 P08684 4/20 0.78
▸ LMNA P02545 3/20 0.78
▸ SMN1; SMN2 Q16637 3/20 0.78
▸ SHBG P04278 2/20 0.78
▸ PMP22 Q01453 2/20 0.78
▸ CYP2D6 P10635 1/20 0.78
▸ ALDH1A1 P00352 1/20 0.78
▸ KCNA1 Q09470 1/20 0.78
▸ SLC47A1 Q96FL8 1/20 0.78
▸ HIF1A Q16665 4/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cortisone Acetate SCHEMBL10301195 1.00 FNTA (1.00) FNTAFNTBNR3C1TSHRKMT2A
Cortisone Acetate SCHEMBL4501 1.00 FNTA (1.00) FNTAFNTBNR3C1TSHRKMT2A
Cortisone Acetate SCHEMBL9819556 1.00 FNTA (1.00) FNTAFNTBNR3C1TSHRKMT2A
SCHEMBL3403149 0.89 FNTA (0.86) FNTAFNTBNR3C1TSHRKMT2A
Cortisone Acetate SCHEMBL19463054 0.89 HIF1A (0.81) FNTAFNTBNR3C1TSHRKMT2A
Cortisone Acetate SCHEMBL19463056 0.89 HIF1A (0.81) FNTAFNTBNR3C1TSHRKMT2A
SCHEMBL25774026 0.89 FNTA (0.80) FNTAFNTBNR3C1TSHRKMT2A
SCHEMBL21790153 0.88 FNTA (0.82) FNTAFNTBNR3C1TSHRKMT2A
SCHEMBL19644910 0.88 FNTA (0.79) FNTAFNTBNR3C1TSHRKMT2A
Cortisone SCHEMBL6535496 0.88 HSD17B10 (1.00) FNTAFNTBNR3C1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4997823-A Antibiotics SYNTEX (U.S.A.) INC. (US) 1991-03-05 — — US disclosed