Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9819991 | 0.88 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9820034 | 0.88 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9820068 | 0.88 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9820131 | 0.88 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1ALDH1A1 | |
| Bromide SCHEMBL27878713 | 0.78 | NPSR1 (0.43) | NPSR1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL27373067 | 0.76 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL27676694 | 0.76 | NPSR1 (0.44) | NPSR1MEN1KMT2AL3MBTL1TSHR | |
| Fluoride SCHEMBL28405683 | 0.74 | NPSR1 (0.43) | NPSR1MEN1KMT2AL3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL28248836 | 0.74 | NPSR1 (0.43) | NPSR1MEN1KMT2AL3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL9820040 | 0.73 | MEN1 (0.41) | NPSR1MEN1KMT2AL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182299-B1 | A CURABLE FLUOROELASTOMER COMPOSITION | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4748208-A | FLUOROPOLYMER, BIS/PHOSPHINE/IMINIUM HALIDE, POLYHYDROXY CURING AGENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1988-05-31 | — | — | US | disclosed |
| EP-0182299-A2 | A curable fluoroelastomer composition | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-05-28 | — | — | EP | disclosed |