Sugi Predict

Sugi Predict / Compounds / SCHEMBL9820164

SCHEMBL9820164

SCHEMBL9820164

Cc1cc(Cl)c(C#N)c(Cl)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.46
▸ ALDH1A1 P00352 7/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ HSD17B10 Q99714 3/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ HPGD P15428 4/20 0.42
▸ PPARG P37231 1/20 0.42
▸ STAT3 P40763 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ RXFP1 Q9HBX9 1/20 0.42
▸ NR2E3 Q9Y5X4 1/20 0.42
▸ NCOR2 Q9Y618 1/20 0.42
▸ RECQL P46063 2/20 0.39
▸ CYP1A2 P05177 3/20 0.38
▸ CYP2C19 P33261 3/20 0.38
▸ CYP2C9 P11712 2/20 0.38
▸ GAA P10253 2/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30630982 1.00 KDM4E (0.46) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL29420807 0.83 KDM4E (0.60) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL318407 0.83 KDM4E (0.60) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL9454917 0.83 KDM4E (0.46) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL15173661 0.80 KDM4E (0.43) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL14967522 0.80 KDM4E (0.43) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL22990661 0.79 HTT (0.42) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL30402943 0.78 L3MBTL1 (0.40) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL28287225 0.78 L3MBTL1 (0.40) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A
SCHEMBL5235265 0.77 TSHR (0.49) KDM4EALDH1A1L3MBTL1HSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12612390-B2 Modulators of methyl modifying enzymes, compositions and uses thereof CONSTELLATION PHARMACEUTICALS, INC. (US) 2026-04-28 — — US disclosed
CN-119954787-A Modulators of methyl-modified enzymes, compositions and uses thereof 星座制药公司 2025-05-09 — — CN disclosed
CN-111989325-B Modulators of methyl-modified enzymes, compositions and uses thereof 星座制药公司 2025-02-25 — — CN disclosed
EP-4421072-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF Constellation Pharmaceuticals, Inc. (US) 2024-08-28 — — EP disclosed
CN-113677341-B Bicyclic pyridine compositions and methods for their use in cancer treatment 南卡罗莱纳大学 2024-07-05 — — CN disclosed
US-20240216357-A1 POLYCYCLIC COMPOUND AND APPLICATION THEREOF SICHUAN HUIYU PHARMACEUTICAL CO., LTD. (CN) 2024-07-04 — — US disclosed
US-20240216357-A1 POLYCYCLIC COMPOUND AND APPLICATION THEREOF SICHUAN HUIYU PHARMACEUTICAL CO., LTD. (CN) 2024-07-04 — — US disclosed
US-20240216357-A1 POLYCYCLIC COMPOUND AND APPLICATION THEREOF SICHUAN HUIYU PHARMACEUTICAL CO., LTD. (CN) 2024-07-04 — — US disclosed
EP-3630291-B9 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 — — EP disclosed
EP-4374858-A2 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2024-05-29 — — EP disclosed
US-20150011546-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. 2015-01-08 — — US disclosed
US-20150011546-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. 2015-01-08 — — US disclosed
EP-2812001-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF Constellation Pharmaceuticals, Inc. (US) 2014-12-17 — — EP disclosed
WO-2014151142-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2014-09-25 — — WO disclosed
WO-2014151142-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2014-09-25 — — WO disclosed
WO-2014100646-A1 1,4-PYRIDONE COMPOUNDS Epizyme, Inc. (US) 2014-06-26 — — WO disclosed
WO-2013120104-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2013-08-15 — — WO disclosed
EP-0104876-B1 HERBICIDAL CYCLOHEXANE-1,3-DIONE DERIVATIVES ICI AUSTRALIA LIMITED (AU) 1991-12-27 — — EP disclosed
US-4631081-A Herbicidal cyclohexane-1,3-dione derivatives ICI AUSTRALIA LIMITED (AU) 1986-12-23 — — US disclosed
EP-0104876-A2 Herbicidal cyclohexane-1,3-dione derivatives ICI AUSTRALIA LIMITED (AU) 1984-04-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150011546-A1 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF TET1, TET3, EHMT2 KDM4E 76/4885ALDH1A1 1213/4885L3MBTL1 925/4885
US-20240216357-A1 POLYCYCLIC COMPOUND AND APPLICATION THEREOF KDM1A, TET1, KDM3A KDM4E 40/4885ALDH1A1 460/4885L3MBTL1 1082/4885
US-12612390-B2 Modulators of methyl modifying enzymes, compositions and uses thereof NSD1, DOT1L, EHMT2 KDM4E 57/4885ALDH1A1 2327/4885L3MBTL1 1806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.