Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9446978 | 0.97 | CYSLTR1 (0.49) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 | |
| SCHEMBL9447082 | 0.89 | CYSLTR1 (0.46) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 | |
| SCHEMBL9447067 | 0.79 | AR (0.64) | GPBAR1CYSLTR1CYSLTR2ALOX5PDE10A | |
| SCHEMBL9447118 | 0.79 | CYSLTR1 (0.66) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 | |
| SCHEMBL9447014 | 0.76 | CYSLTR1 (0.44) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 | |
| SCHEMBL10660991 | 0.76 | CYSLTR1 (0.69) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 | |
| SCHEMBL5210269 | 0.75 | AR (0.64) | MAPK1PTGS1MRGPRX1MAPTL3MBTL1 | |
| SCHEMBL28143636 | 0.75 | KDM4E (0.51) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL9447068 | 0.75 | SLC40A1 (0.48) | CYSLTR1CYSLTR2MEN1ALDH1A1KMT2A | |
| SCHEMBL9447005 | 0.74 | CYSLTR1 (0.45) | GPBAR1CYSLTR1CYSLTR2MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399291-A3 | SUBSTITUTED (QUINOLINE-2-YL-METHOXY)PHENYL-ACYL-SULPHONAMIDES AND CYANAMIDES , PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0399291-A2 | Substituted (Quinoline-2-yl-methoxy)phenyl-acyl-sulphonamides and cyanamides , process for their preparation and their use in medicines | BAYER AG (DE) | 1990-11-28 | — | — | EP | disclosed |