Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052788 | 0.89 | CYP4F2 (0.53) | ESR1ESR2 | |
| SCHEMBL23360606 | 0.85 | GABRA1 (0.46) | ESR1ESR2 | |
| SCHEMBL9837746 | 0.85 | CYP4F2 (0.62) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL9838425 | 0.85 | CYP4F2 (0.62) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL1019684 | 0.85 | CYP4F2 (0.62) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL29586758 | 0.85 | CYP4F2 (0.62) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL9838132 | 0.82 | ESR1 (0.56) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL7111420 | 0.82 | ESR1 (0.56) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL7111422 | 0.82 | ESR1 (0.56) | ESR1ESR2DRD2DRD1DRD4 | |
| SCHEMBL24496703 | 0.81 | ESR1 (0.52) | ESR1ESR2DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292977-B1 | ALKOXY-SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATE DERIVATIVES | G.D. Searle & Co. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4889871-A | ANTIINFLAMMATORY AGENTS; SELECTIVE LEUKOTRIENE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0292977-A1 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives | G.D. Searle & Co. (US) | 1988-11-30 | — | — | EP | disclosed |