SCHEMBL9822648

SCHEMBL9822648

O=C(O)c1c(-c2ccccc2)oc(-c2ccccc2)cc1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.53
KDM4E B2RXH2 7/20 0.50
POLB P06746 2/20 0.50
SMN1; SMN2 Q16637 8/20 0.49
HPGD P15428 6/20 0.49
CYP19A1 P11511 5/20 0.49
CYP1B1 Q16678 5/20 0.49
TP53 P04637 5/20 0.49
CYP3A4 P08684 5/20 0.49
ABCB1 P08183 4/20 0.49
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
CA12 O43570 3/20 0.49
CA1 P00915 3/20 0.49
CA2 P00918 3/20 0.49
CA9 Q16790 3/20 0.49
AR P10275 3/20 0.49
GABRP O00591 3/20 0.49
GABRD O14764 3/20 0.49
GABRA1 P14867 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11551192 0.83 PDE4A (0.50) PDE4AKDM4EPOLBSMN1; SMN2HPGD
SCHEMBL10462843 0.83 TNKS (0.51) PDE4AKDM4ESMN1; SMN2HPGDCYP19A1
SCHEMBL10572451 0.82 KDM4E (0.47) PDE4AKDM4EPOLBSMN1; SMN2HPGD
SCHEMBL10462774 0.79 MEN1 (0.57) KDM4EHPGDTP53TNKSMAPT
SCHEMBL11551382 0.77 CCNC (0.48) PDE4AKDM4EPOLBSMN1; SMN2HPGD
SCHEMBL11552267 0.77 CCNC (0.48) PDE4AKDM4EPOLBSMN1; SMN2HPGD
SCHEMBL2808423 0.77 NR4A2 (0.55) PDE4AKDM4ESMN1; SMN2HPGDNPC1
SCHEMBL4499269 0.77 PDE4A (0.72) PDE4AKDM4EPOLBSMN1; SMN2HPGD
SCHEMBL11555120 0.76 TNKS (0.46) PDE4AKDM4EPOLBHPGDCYP1B1
SCHEMBL11555723 0.76 KDM4E (0.47) PDE4AKDM4EPOLBSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0173050-B1 SELECTED 2,2,6,6-TETRAMETHYL-4-PIPERIDINYL DERIVATIVES AND THEIR USE AS LIGHT STABILIZERS OLIN CORPORATION (US) 1991-11-13 EP disclosed
EP-0173050-A2 Selected 2,2,6,6-tetramethyl-4-piperidinyl derivatives and their use as light stabilizers OLIN CORPORATION (US) 1986-03-05 EP disclosed
US-4548973-A SUNSCREENS OLIN CORPORATION (US) 1985-10-22 US disclosed