Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.75 |
| ▸ | HPGD | P15428 | 8/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.75 |
| ▸ | CA1 | P00915 | 2/20 | 0.75 |
| ▸ | CA9 | Q16790 | 2/20 | 0.75 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.75 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.75 |
| ▸ | CA12 | O43570 | 1/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.75 |
| ▸ | CA4 | P22748 | 1/20 | 0.75 |
| ▸ | CA6 | P23280 | 1/20 | 0.75 |
| ▸ | CA7 | P43166 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL31332109 | 0.98 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL25288775 | 0.98 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL30297957 | 0.96 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL27732770 | 0.96 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL30297915 | 0.96 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL28175461 | 0.94 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL1829341 | 0.91 | ALDH1A1 (0.82) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL28163981 | 0.90 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL1003308 | 0.89 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ECA1CA9 | |
| Salicylic Acid SCHEMBL980591 | 0.89 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ECA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031328-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD (US) | 2014-01-30 | — | — | US | claimed |
| US-20110021484-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD | 2011-01-27 | — | — | US | claimed |
| EP-2262509-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | Bernstein, Lawrence (US) | 2010-12-22 | — | — | EP | claimed |
| WO-2009111681-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | BERNSTEIN LAWRENCE (US) | 2009-09-11 | — | — | WO | claimed |
| US-20140031328-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD (US) | 2014-01-30 | — | — | US | disclosed |
| US-20110021484-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD | 2011-01-27 | — | — | US | disclosed |
| EP-2262509-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | Bernstein, Lawrence (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009111681-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | BERNSTEIN LAWRENCE (US) | 2009-09-11 | — | — | WO | disclosed |