Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9822758 | 0.89 | DRD2 (0.40) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| Methane SCHEMBL9867076 | 0.89 | DRD2 (0.40) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL9866810 | 0.88 | DRD2 (0.39) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL9822852 | 0.88 | DRD2 (0.46) | DRD2 | |
| Hydrochloric Acid SCHEMBL10810407 | 0.87 | DRD2 (0.50) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL9867141 | 0.86 | DRD2 (0.46) | DRD2 | |
| SCHEMBL10812090 | 0.85 | — | — | |
| SCHEMBL10805966 | 0.84 | DRD2 (0.40) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL10804226 | 0.84 | DRD2 (0.42) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL9877847 | 0.84 | DRD2 (0.42) | DRD2DRD3ADRA2BADRA2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231139-B1 | DIHYDROBENZOFURANE AND CHROMANE CARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEUROLEPTICS | Laboratoires DELAGRANGE (FR) | 1991-12-04 | — | — | EP | claimed |
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |