Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10781927 | 0.88 | DRD2 (0.70) | DRD2HTR1ADRD4 | |
| SCHEMBL10836726 | 0.87 | DRD2 (0.73) | DRD2HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL10782020 | 0.86 | DRD2 (0.70) | DRD2HTR1ADRD4 | |
| SCHEMBL10787025 | 0.86 | DRD2 (0.68) | DRD2HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL10836083 | 0.86 | DRD2 (0.73) | DRD2HTR1ADRD4 | |
| SCHEMBL9539310 | 0.86 | DRD2 (0.64) | DRD2HTR1ADRD4 | |
| SCHEMBL9587786 | 0.85 | DRD2 (0.70) | DRD2HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL10787472 | 0.85 | DRD2 (0.69) | DRD2HTR1ADRD4 | |
| SCHEMBL10783585 | 0.85 | DRD2 (0.66) | DRD2HTR1ADRD4 | |
| SCHEMBL10835599 | 0.85 | DRD2 (0.69) | DRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | claimed |
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | claimed |
| EP-0286263-A1 | Psychotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-12 | — | — | EP | claimed |
| WO-1988007529-A1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | claimed |
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4824999-A | INTERMEDIATES FOR ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0286263-A1 | Psychotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-12 | — | — | EP | disclosed |