Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 7/20 | 0.41 |
| ▸ | THRA | P10827 | 5/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30207653 | 0.86 | MEN1 (0.45) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL7919792 | 0.81 | MEN1 (0.56) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL10584307 | 0.79 | KMT2A (0.52) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL7829095 | 0.78 | MEN1 (0.58) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL7909905 | 0.77 | KMT2A (0.58) | MEN1NR1I2KMT2ATHRBTHRA | |
| Diclazuril SCHEMBL126138 | 0.74 | MEN1 (1.00) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL6493238 | 0.72 | KMT2A (0.78) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL8603426 | 0.72 | KMT2A (0.54) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL5566893 | 0.71 | MEN1 (0.56) | MEN1NR1I2KMT2ATHRBTHRA | |
| SCHEMBL10420205 | 0.71 | MEN1 (0.82) | MEN1NR1I2KMT2ATHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232932-B1 | 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-02 | — | — | EP | disclosed |
| EP-0232932-A1 | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-19 | — | — | EP | disclosed |