SCHEMBL7919792

SCHEMBL7919792

O=c1cnn(-c2cc(Cl)cc(Cl)c2)c(=O)[nH]1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.56
NR1I2 O75469 1/20 0.56
KMT2A Q03164 1/20 0.56
THRB P10828 8/20 0.47
THRA P10827 4/20 0.47
P2RX7 Q99572 9/20 0.43
ABCB11 O95342 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7909905 0.84 KMT2A (0.58) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL9166052 0.83 MEN1 (0.54) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL7922440 0.82 KMT2A (0.41) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL9823286 0.81 MEN1 (0.58) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL29414732 0.80 THRB (0.49) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL11460749 0.79 MEN1 (0.51) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL9500887 0.77 MEN1 (0.58) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL6342801 0.77 MEN1 (0.71) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL7829095 0.77 MEN1 (0.58) MEN1NR1I2KMT2ATHRBTHRA
SCHEMBL5566665 0.77 MEN1 (0.58) MEN1NR1I2KMT2ATHRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211178-B1 ANTIPROTOZOA AGENTS FOR COCCIDIOIDES; CYCLIZATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
US-5994355-A ANTIPROTOZOA AGENTS, PARASITICIDE; VETERINARY MEDICINE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-30 US disclosed
EP-0648760-B1 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-01-27 EP disclosed