SCHEMBL9823341

SCHEMBL9823341

COC(=O)/C=C/c1cc(C)no1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.52
HDAC2 Q92769 1/20 0.52
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
HSD17B10 Q99714 2/20 0.42
TTR P02766 1/20 0.41
APP P05067 1/20 0.41
IP6K1 Q92551 1/20 0.41
IP6K3 Q96PC2 1/20 0.41
IP6K2 Q9UHH9 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
TYR P14679 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
ALDH1A1 P00352 3/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18237505 0.82 HDAC1 (0.54) HDAC1HDAC2CYP1A2ALDH1A1KDM4E
SCHEMBL18237506 0.82 HDAC1 (0.54) HDAC1HDAC2CYP1A2ALDH1A1KDM4E
SCHEMBL9823482 0.81 HDAC1 (0.52) HDAC1HDAC2CYP1A2CYP2C19HSD17B10
SCHEMBL11001540 0.81 HDAC1 (0.52) HDAC1HDAC2ALDH1A1MAPTKDM4E
SCHEMBL11001535 0.81 HDAC1 (0.52) HDAC1HDAC2ALDH1A1MAPTKDM4E
SCHEMBL9823480 0.81 HDAC1 (0.52) HDAC1HDAC2CYP1A2CYP2C19HSD17B10
SCHEMBL17537884 0.74 CA12 (0.53) HDAC1CYP1A2CYP2C19HSD17B10TTR
SCHEMBL24150044 0.71 CA12 (0.42) CYP1A2CYP2C19HSD17B10TTRAPP
SCHEMBL17936932 0.71 KMT2A (0.45) CYP1A2CYP2C19HSD17B10TTRAPP
SCHEMBL5704559 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0208040-B1 RHODANINE DERIVATIVES AND A PROCESS FOR PREPARING SAME TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1991-08-14 EP disclosed
US-4777259-A ALDOSE REDUCTASE INHIBITOR TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1988-10-11 US disclosed
EP-0258914-A2 Rhodanine derivatives and a process for preparing same TAIHO PHARMACEUTICAL CO., LTD. (JP) 1988-03-09 EP disclosed
US-4714765-A Rhodanine derivatives and process for preparing the same TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) 1987-12-22 US disclosed
EP-0208040-A2 Rhodanine derivatives and a process for preparing same TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1987-01-14 EP disclosed