Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823465 | 0.88 | DHFR (0.75) | DHFR | |
| SCHEMBL9823610 | 0.87 | DHFR (0.74) | DHFR | |
| SCHEMBL18402522 | 0.87 | DHFR (0.72) | DHFR | |
| SCHEMBL9808429 | 0.87 | — | — | |
| SCHEMBL9823100 | 0.86 | DHFR (0.53) | DHFR | |
| SCHEMBL20094841 | 0.86 | DHFR (0.70) | DHFR | |
| SCHEMBL9823269 | 0.84 | DHFR (1.00) | DHFR | |
| SCHEMBL31490169 | 0.84 | DHFR (0.87) | DHFR | |
| SCHEMBL7263046 | 0.84 | DHFR (0.87) | DHFR | |
| SCHEMBL9808433 | 0.83 | TYMS (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |