⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18593099 | 0.73 | — | — | |
| SCHEMBL21257401 | 0.70 | KDM4E (0.36) | — | |
| SCHEMBL926031 | 0.68 | CRBN (0.48) | — | |
| SCHEMBL8550115 | 0.67 | CRBN (0.52) | — | |
| SCHEMBL17355878 | 0.66 | CRBN (0.35) | — | |
| SCHEMBL21244594 | 0.66 | BRD4 (0.34) | — | |
| SCHEMBL2561850 | 0.65 | CRBN (0.30) | — | |
| SCHEMBL18590510 | 0.65 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL10267710 | 0.64 | CRBN (0.38) | — | |
| SCHEMBL6848122 | 0.64 | CRBN (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023030478-A1 | PYRIDOLACTAM DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2023-03-09 | — | — | WO | disclosed |
| EP-0260644-B1 | PROCESS FOR THE MANUFACTURE OF ALPHA-PYRROLIDONES AND THEIR IMINES | BASF Aktiengesellschaft (DE) | 1991-11-06 | — | — | EP | disclosed |
| US-4962204-A | Preparation of alpha-pyrrolidones and their imines | BASF AKTIENGESELLSCHAFT (DE) | 1990-10-09 | — | — | US | disclosed |
| US-4855444-A | α-pyrrolidones and a method for preparation thereof | BASF AKTIENGESELLSCHAFT (DE) | 1989-08-08 | — | — | US | disclosed |
| EP-0260644-A1 | Process for the manufacture of alpha-pyrrolidones and their imines | BASF Aktiengesellschaft (DE) | 1988-03-23 | — | — | EP | disclosed |