Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19262874 | 0.78 | CRBN (0.43) | CRBNALDH1A1LMNAHPGD | |
| SCHEMBL19852500 | 0.76 | PTPN1 (0.35) | CRBNALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8485336 | 0.74 | CRBN (0.48) | CRBNALDH1A1BRD4CREBBPSMN1; SMN2 | |
| SCHEMBL13210391 | 0.73 | LMNA (0.36) | CRBNALDH1A1LMNAHPGD | |
| SCHEMBL8548434 | 0.73 | LMNA (0.36) | CRBNALDH1A1LMNAHPGD | |
| SCHEMBL25138031 | 0.71 | CRBN (0.56) | CRBNALDH1A1BRD4CREBBP | |
| SCHEMBL10274864 | 0.70 | LMNA (0.34) | ALDH1A1LMNAHPGD | |
| SCHEMBL908288 | 0.69 | — | — | |
| SCHEMBL19696212 | 0.69 | CRBN (0.42) | CRBNALDH1A1BRD4CREBBP | |
| SCHEMBL17646510 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |