Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10394514 | 0.85 | MEN1 (0.58) | MEN1KMT2ANR1I2GAAALDH1A1 | |
| SCHEMBL27278211 | 0.77 | TP53 (0.40) | MEN1KMT2ATP53GAAALDH1A1 | |
| SCHEMBL10395312 | 0.77 | MEN1 (0.67) | MEN1KMT2ANR1I2GAAALDH1A1 | |
| SCHEMBL7919164 | 0.71 | MEN1 (0.65) | MEN1KMT2ANR1I2GAAALDH1A1 | |
| SCHEMBL7919562 | 0.70 | MEN1 (0.67) | MEN1KMT2ANR1I2GAAALDH1A1 | |
| Diclazuril SCHEMBL126138 | 0.69 | MEN1 (1.00) | MEN1KMT2ANR1I2L3MBTL1 | |
| Diclazuril SCHEMBL27803573 | 0.69 | MEN1 (0.64) | MEN1KMT2ANR1I2GAAALDH1A1 | |
| SCHEMBL5566062 | 0.67 | MEN1 (0.42) | MEN1KMT2ANR1I2L3MBTL1LMNA | |
| SCHEMBL7919703 | 0.64 | MEN1 (0.86) | MEN1KMT2ANR1I2L3MBTL1 | |
| SCHEMBL7917028 | 0.62 | MEN1 (0.69) | MEN1KMT2ANR1I2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232932-B1 | 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-02 | — | — | EP | disclosed |
| US-4952570-A | ANTIPROTOZOA AGENTS; COCCIDIOSIS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-28 | — | — | US | disclosed |
| US-4912106-A | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5,(2H,4H)-diones and their use as protozoa combating agents | JANSSEN PHARMACEUTICA N. V. FRAME-319 (BE) | 1990-03-27 | — | — | US | disclosed |
| US-4767760-A | Anti-protozoal 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione derivatives, compositions, and method of use therefor | JANSSEN PHARMACUETICA N.V. (BE) | 1988-08-30 | — | — | US | disclosed |
| EP-0232932-A1 | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-19 | — | — | EP | disclosed |