SCHEMBL9823914

SCHEMBL9823914

Cc1ccc(NC(=O)C(F)(F)F)cc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.55
CYP2C9 P11712 3/20 0.55
CYP2C19 P33261 3/20 0.55
ALDH1A1 P00352 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.54
CYP2D6 P10635 2/20 0.54
GAA P10253 2/20 0.54
MEN1 O00255 1/20 0.54
CYP3A4 P08684 1/20 0.54
KMT2A Q03164 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
NPC1 O15118 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24474072 0.83 KMT2A (0.56) CYP1A2CYP2C9CYP2C19ALDH1A1L3MBTL1
SCHEMBL10829242 0.83 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19ALDH1A1L3MBTL1
SCHEMBL2979786 0.83 CYP1A2 (0.55) CYP1A2CYP2C9CYP2C19ALDH1A1L3MBTL1
SCHEMBL16621003 0.81 SMN1; SMN2 (0.60) CYP1A2CYP2C9CYP2C19ALDH1A1L3MBTL1
SCHEMBL374358 0.81 CYP1A2 (0.54) CYP1A2CYP2C9CYP2C19L3MBTL1GAA
SCHEMBL2853227 0.80 ALDH1A1 (0.64) CYP1A2CYP2C9CYP2C19ALDH1A1CYP2D6
SCHEMBL9823940 0.79 MEN1 (0.52) CYP1A2CYP2C9CYP2C19L3MBTL1GAA
SCHEMBL14720938 0.79 CA12 (0.54) CYP1A2CYP2C9CYP2C19L3MBTL1GAA
SCHEMBL6540259 0.79 CYP1A2 (0.55) CYP1A2CYP2C9CYP2C19L3MBTL1GAA
SCHEMBL20646201 0.79 CYP1A2 (0.77) CYP1A2CYP2C9CYP2C19ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0269914-B1 COMPOSITION AND PROCESS FOR THE OXIDATIVE DYEING OF HAIR ON THE BASIS OF 3-(2',2',2'-TRIFLUORETHYL)AMINOPHENOL DERIVATIVES, AND 3-(2',2',2'-TRIFLUORETHYL)AMINOPHENOL DERIVATIVES Wella Aktiengesellschaft (DE) 1991-06-12 EP disclosed
US-4923479-A HAIR DYES WELLA AKTIENGESELLSCHAFT (DE) 1990-05-08 US disclosed
WO-1988004166-A1 HAIR DYEING OXIDISING AGENT AND PROCESS WITH 3-(2',2',2'-TRIFLUOROETHYL)AMINO-PHENOL DERIVATES AND NEW 3-(2',2',2'-TRIFLUOROETHYL)AMINO-PHENOL DERIVATES WELLA AKTIENGESELLSCHAFT (DE) 1988-06-16 WO disclosed