Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307481 | 0.98 | ALOX15 (0.48) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL9824858 | 0.89 | HRH3 (0.45) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL9824301 | 0.87 | HRH3 (0.48) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL9824505 | 0.83 | ALOX15 (0.41) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL11410375 | 0.83 | ALOX15 (0.55) | ALOX15PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL10153844 | 0.83 | CYP1A2 (0.54) | CARM1PRMT6PRMT8CYP1A2CHRM5 | |
| SCHEMBL20284518 | 0.82 | CYP1A2 (0.46) | CYP1A2CHRM5ADRA2CHRH3ACHE | |
| SCHEMBL12945 | 0.81 | CHRM5 (0.58) | CYP1A2CHRM5ADRA2CHRH3SIGMAR1 | |
| SCHEMBL3218288 | 0.81 | CHRM5 (0.58) | CYP1A2CHRM5ADRA2CHRH3SIGMAR1 | |
| SCHEMBL30340999 | 0.81 | CHRM5 (0.58) | CYP1A2CHRM5ADRA2CHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |