Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209414 | 0.93 | GRK6 (0.39) | ENPP2GRK6ADRB2NPC1RAB9A | |
| SCHEMBL10573336 | 0.91 | TSHR (0.36) | ENPP2GRK6ADRB2NPC1RAB9A | |
| SCHEMBL9824347 | 0.90 | GRK6 (0.39) | ENPP2GRK6ADRB2NPC1RAB9A | |
| SCHEMBL10577299 | 0.88 | TSHR (0.37) | ENPP2GRK6ADRB2NPC1RAB9A | |
| SCHEMBL9824468 | 0.85 | ENPP2 (0.42) | ENPP2RXFP1ALDH1A1TSHRKDM4E | |
| SCHEMBL9824865 | 0.83 | GRK6 (0.42) | ENPP2GRK6NPC1RAB9AALDH1A1 | |
| SCHEMBL6222050 | 0.82 | STAT3 (0.41) | ENPP2GRK6NPC1RAB9AALDH1A1 | |
| SCHEMBL10574090 | 0.80 | CNR1 (0.39) | ENPP2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9824096 | 0.80 | KDM4E (0.43) | ENPP2ALDH1A1KDM4EMAPTSTAT3 | |
| SCHEMBL10573005 | 0.79 | GRK6 (0.42) | GRK6NPC1RAB9AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4880814-A | 7-cycloalkyl naphthyridines | ABBOTT LABORATORIES (US) | 1989-11-14 | — | — | US | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |