Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341405 | 0.91 | GRIN2B (0.51) | GRIN2BCRBNHTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL7365761 | 0.89 | GRIN2B (0.49) | GRIN2BCRBNHTR1AHTR2AHTR7 | |
| SCHEMBL11045067 | 0.82 | CRBN (0.57) | CRBNKDM4ELMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10680012 | 0.80 | MAOB (0.56) | GRIN2BKDM4ELMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9824534 | 0.80 | NR3C1 (0.59) | GRIN2BCRBNKDM4ELMNAMEN1 | |
| SCHEMBL9825269 | 0.80 | CRBN (0.58) | GRIN2BCRBNHTR1ADRD2HTR2A | |
| SCHEMBL5843055 | 0.80 | GRIN2B (0.58) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL7288177 | 0.79 | GRIN2B (0.57) | GRIN2BCRBNHTR1ADRD2HTR2A | |
| SCHEMBL9824610 | 0.79 | KMT2A (0.61) | GRIN2BCRBNHTR1ADRD2HTR2A | |
| SCHEMBL7564279 | 0.79 | GRIN2B (0.57) | GRIN2BHTR1ADRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168003-B1 | OXINDOL COMPOUNDS, COMPOSITIONS CONTAINING SAME AND PROCESSES FOR PREPARING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4737501-A | Substituted piperazinyl oxindol compounds and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| EP-0168003-A1 | Oxindol compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |