Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824639 | 0.85 | S1PR1 (0.42) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL9825242 | 0.84 | CARM1 (0.41) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL10566949 | 0.81 | TSHR (0.43) | S1PR1S1PR3S1PR5PKMTSHR | |
| SCHEMBL9824822 | 0.81 | S1PR1 (0.37) | S1PR1S1PR3S1PR5S1PR4CYP1A2 | |
| SCHEMBL12477659 | 0.79 | CARM1 (0.38) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL16373740 | 0.77 | CARM1 (0.44) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL9824094 | 0.75 | CARM1 (0.39) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL9824501 | 0.74 | S1PR1 (0.40) | S1PR1S1PR3S1PR5PRMT6CARM1 | |
| SCHEMBL9824289 | 0.73 | OPRM1 (0.35) | S1PR1S1PR3S1PR5CYP1A2SIGMAR1 | |
| SCHEMBL3930116 | 0.73 | S1PR1 (0.33) | S1PR1S1PR3S1PR5CYP1A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |