SCHEMBL9825003

SCHEMBL9825003

Cc1cn(C)c2c1N(C(=O)NCCN1CCCCC1CN1CCCCCC1)c1ccccc1NC2=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.50
MEN1 O00255 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
ALOX15 P16050 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.47
CHRM4 P08173 1/20 0.47
CHRM5 P08912 1/20 0.47
CHRM1 P11229 1/20 0.47
CHRM3 P20309 1/20 0.47
HRH3 Q9Y5N1 3/20 0.40
BCHE P06276 2/20 0.38
ACHE P22303 2/20 0.38
TP53 P04637 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
USP2 O75604 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9824970 0.88 CHRM2 (0.59) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL9824998 0.87 CHRM2 (0.47) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL9825377 0.86 CHRM2 (0.68) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL9824376 0.83 CYP1A2 (0.54) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL9824070 0.78 CHRM2 (0.67) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL10966830 0.77 ALDH1A1 (0.55) CHRM2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9824136 0.77 CHRM2 (0.49) CHRM2MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL9667442 0.76 CYP3A4 (0.36) CHRM2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL10969123 0.76 ALDH1A1 (0.56) CHRM2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9824018 0.76 CHRM2 (0.75) CHRM2MEN1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273239-B1 CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1991-03-06 EP disclosed
US-4873236-A BRADYCARDIAL AGENTS DR. KARL THOMAE GMBH (DE) 1989-10-10 US disclosed
EP-0273239-A1 Condensed diazepinones, processes for their preparation and medicaments containing them Dr. Karl Thomae GmbH (DE) 1988-07-06 EP disclosed