SCHEMBL9825262

SCHEMBL9825262

CC1(C)CC(=O)c2ccc(OCCCCl)cc2O1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.67
ALDH1A1 P00352 4/20 0.60
NPC1 O15118 2/20 0.60
RAB9A P51151 2/20 0.60
MAPT P10636 1/20 0.60
KDM4E B2RXH2 3/20 0.55
MAPK1 P28482 1/20 0.54
GLA P06280 1/20 0.54
GAA P10253 1/20 0.54
HPGD P15428 1/20 0.54
CASP1 P29466 1/20 0.54
CASP7 P55210 1/20 0.54
HSD17B10 Q99714 1/20 0.54
ADRB2 P07550 4/20 0.52
ADRB1 P08588 4/20 0.52
PDE4B Q07343 1/20 0.51
ADRB3 P13945 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10610580 0.91 MAOB (0.67) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL10609734 0.88 MAOB (0.67) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL11360006 0.85 MAOB (0.63) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL10403860 0.83 MAOB (0.67) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL10403216 0.83 MAOB (0.67) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL3958511 0.82 MAOB (0.66) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL27953579 0.81 ALDH1A1 (0.59) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL10402678 0.81 MAOB (0.65) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL10608614 0.81 MAOB (0.65) MAOBALDH1A1NPC1RAB9AMAPT
SCHEMBL5717611 0.81 ALDH1A1 (0.81) MAOBALDH1A1NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0237781-B1 PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS WARNER-LAMBERT COMPANY (US) 1991-04-24 EP disclosed
US-4803203-A SCHIZOPHRENIA, NEUOLEPTIC AGENTS WARNER-LAMBERT COMPANY (US) 1989-02-07 US disclosed
US-4704390-A SCHIZOPHRENIA WARNER-LAMBERT COMPANY (US) 1987-11-03 US disclosed
EP-0237781-A2 Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents WARNER-LAMBERT COMPANY (US) 1987-09-23 EP disclosed