Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 12/20 | 0.81 |
| ▸ | NMBR | P28336 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070447 | 0.91 | TGM2 (0.86) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4931009 | 0.91 | TGM2 (0.86) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4597486 | 0.91 | TGM2 (0.86) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4299691 | 0.89 | TGM2 (1.00) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL1092215 | 0.89 | TGM2 (0.83) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL1092213 | 0.89 | TGM2 (0.83) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL5143184 | 0.89 | TGM2 (0.83) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4305321 | 0.85 | TGM2 (1.00) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4302162 | 0.83 | TGM2 (1.00) | TGM2NMBRMAPTGAAHTT | |
| SCHEMBL4935366 | 0.83 | TGM2 (0.73) | TGM2NMBRMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | claimed |
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |