SCHEMBL9825588

SCHEMBL9825588

COc1c2cccccc-2c2occc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.46
CYP1A1 P04798 4/20 0.46
CYP1B1 Q16678 4/20 0.46
CYP1A2 P05177 3/20 0.46
HPGD P15428 3/20 0.46
KDM4E B2RXH2 2/20 0.46
POLB P06746 1/20 0.46
PTPN1 P18031 1/20 0.46
ALDH1A1 P00352 3/20 0.45
ALOX15 P16050 1/20 0.45
KCNA3 P22001 6/20 0.45
NLRP3 Q96P20 1/20 0.43
CYP2D6 P10635 2/20 0.41
MAPK1 P28482 2/20 0.41
CYP2C19 P33261 2/20 0.41
PDE4A P27815 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9826368 0.80 CYP3A4 (0.42) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
SCHEMBL28111 0.77 ALDH1A1 (0.60) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
SCHEMBL9127225 0.65 KCNA3 (0.78) ALDH1A1KCNA3MAPK1MAPT
SCHEMBL30096399 0.64 CYP3A4 (0.68) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
SCHEMBL11539828 0.64 KCNA3 (0.60) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
SCHEMBL30973566 0.63 CYP3A4 (0.43) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
SCHEMBL10821323 0.63 KCNA3 (0.78) KCNA3
Isopimpinellin SCHEMBL29568822 0.63 CYP3A4 (1.00) CYP3A4CYP1A1CYP1B1CYP1A2HPGD
Dictamnine SCHEMBL1760700 0.63 POLB (0.65) CYP3A4CYP1A2HPGDKDM4EPOLB
Isopimpinellin SCHEMBL498907 0.63 CYP3A4 (1.00) CYP3A4CYP1A1CYP1B1CYP1A2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5037575-A Photostability MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) 1991-08-06 US disclosed
EP-0187015-B1 SQUARILIUM COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME MITSUBISHI KASEI CORPORATION (JP) 1991-05-29 EP disclosed