Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 8/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367086 | 0.82 | MEN1 (0.63) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL2216839 | 0.78 | MAPT (1.00) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL9825278 | 0.78 | MEN1 (0.67) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL9825818 | 0.78 | MEN1 (0.67) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL11219235 | 0.77 | HRH1 (0.80) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL10489982 | 0.77 | DRD2 (0.69) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL9825826 | 0.76 | MEN1 (0.67) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL11273968 | 0.76 | HRH1 (0.78) | MEN1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL20512980 | 0.75 | DRD2 (0.81) | DRD2 | |
| SCHEMBL29786358 | 0.75 | DRD2 (0.81) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |