Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824742 | 1.00 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| SCHEMBL9689815 | 1.00 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL9826083 | 0.99 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL29506964 | 0.99 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| SCHEMBL10692431 | 0.99 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL9825988 | 0.99 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL10689374 | 0.99 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| SCHEMBL9824640 | 0.99 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| SCHEMBL9825379 | 0.99 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CKMT2AMAPT | |
| SCHEMBL9825774 | 0.98 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167371-B1 | DIHYDROPYRIDINE COMPOUNDS, THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-03-06 | — | — | EP | claimed |
| US-4727082-A | CARDIOVASCULAR DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | claimed |
| EP-0167371-A2 | Dihydropyridine compounds, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-01-08 | — | — | EP | claimed |
| US-20230346820-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 | THE SCRIPPS RESEARCH INSTITUTE | 2023-11-02 | — | — | US | disclosed |
| EP-0167371-B1 | DIHYDROPYRIDINE COMPOUNDS, THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4843085-A | LOCAL ANESTHETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| US-4727082-A | CARDIOVASCULAR DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| EP-0167371-A2 | Dihydropyridine compounds, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346820-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 | ACE2, SARS1, ACE | ADRA2A 1438/4885ADRA2B 1817/4885ADRA2C 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.