Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826397 | 0.86 | TGM2 (0.69) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL9825336 | 0.86 | TGM2 (0.69) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL9825801 | 0.86 | TGM2 (0.55) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL9825517 | 0.83 | TGM2 (0.75) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL4598750 | 0.83 | TGM2 (0.70) | CTSLCTSSCTSKL3MBTL1TGM2 | |
| SCHEMBL9825585 | 0.83 | TGM2 (0.55) | CTSLCTSSCTSKL3MBTL1TGM2 | |
| SCHEMBL9825686 | 0.83 | TGM2 (0.54) | CTSLCTSSCTSKL3MBTL1TGM2 | |
| SCHEMBL9826986 | 0.82 | TGM2 (0.66) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL9825545 | 0.81 | TGM2 (0.54) | CTSLCTSSCTSKTGM2CTSB | |
| SCHEMBL9827308 | 0.80 | TGM2 (0.63) | CTSLCTSSCTSKTGM2CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |