Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104212 | 1.00 | NPSR1 (0.43) | NPSR1CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL10670140 | 0.83 | ACE (0.52) | — | |
| SCHEMBL10670150 | 0.83 | ACE (0.52) | — | |
| SCHEMBL7369254 | 0.83 | F2 (0.49) | NPSR1CCKBR | |
| SCHEMBL7369250 | 0.83 | F2 (0.49) | NPSR1CCKBR | |
| SCHEMBL8895762 | 0.80 | CCKBR (0.56) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL10850704 | 0.77 | ACE (0.51) | — | |
| SCHEMBL10850708 | 0.77 | ACE (0.51) | — | |
| SCHEMBL19586294 | 0.76 | NPSR1 (0.71) | NPSR1 | |
| SCHEMBL10668403 | 0.76 | ACE (0.50) | NPSR1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125056-B1 | CONDENSED, SEVEN-MEMBERED RING COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-01-16 | — | — | EP | disclosed |
| US-4739066-A | HYPOTENSIVE AGENTS, ANGIOTENSIN INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| US-4638000-A | HYPOTENSIVES, ANGIOTENSIN INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-01-20 | — | — | US | disclosed |
| US-4564612-A | ANGIOTENSION CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS, BENZOTHIAZEPINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| EP-0156455-A2 | Condensed seven-membered ring compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-10-02 | — | — | EP | disclosed |
| EP-0125056-A2 | Condensed, seven-membered ring compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-11-14 | — | — | EP | disclosed |