Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8651071 | 0.87 | SNCA (0.42) | TSHRALDH1A1HSD17B10SNCAMAPT | |
| Bromide SCHEMBL9827145 | 0.84 | TSHR (0.44) | TSHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL10003354 | 0.79 | CYP4F2 (0.60) | CYP4F2CYP4A11TSHRBAZ2BBAZ2A | |
| Bromide SCHEMBL9826440 | 0.79 | SMN1; SMN2 (0.58) | ALDH1A1SNCACA12CA1CA2 | |
| Bromide SCHEMBL7025256 | 0.78 | CYP4F2 (0.56) | CYP4F2CYP4A11ALDH1A1SNCACA2 | |
| SCHEMBL522636 | 0.77 | CYP4F2 (0.57) | CYP4F2CYP4A11TSHRBAZ2BBAZ2A | |
| Bromide SCHEMBL3918746 | 0.76 | TSHR (0.57) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| Bromide SCHEMBL21176866 | 0.76 | L3MBTL1 (0.47) | TSHRALDH1A1MAPTHPGDLMNA | |
| SCHEMBL20077738 | 0.76 | SMN1; SMN2 (0.57) | CYP4F2CYP4A11TSHRBAZ2BBAZ2A | |
| SCHEMBL6971203 | 0.76 | CYP4F2 (0.78) | CYP4F2CYP4A11TSHRBAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150892-B1 | SUBSTITUTED ALKYLIDENE IMIDAZOLES | G.D. Searle & Co. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4837333-A | SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE ENZYME | G. D. SEARLE & CO. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0150892-A2 | Substituted alkylidene imidazoles | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |