Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826172 | 1.00 | TBXAS1 (0.54) | TBXAS1ALDH1A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9826161 | 1.00 | TBXAS1 (0.54) | TBXAS1ALDH1A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL10551595 | 0.91 | TBXAS1 (0.64) | TBXAS1CYP19A1 | |
| SCHEMBL9826648 | 0.91 | TBXAS1 (0.64) | TBXAS1CYP19A1 | |
| SCHEMBL10551602 | 0.91 | TBXAS1 (0.64) | TBXAS1CYP19A1 | |
| SCHEMBL9826120 | 0.88 | TBXAS1 (0.48) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9826107 | 0.88 | TBXAS1 (0.48) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9826115 | 0.88 | TBXAS1 (0.48) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9827875 | 0.81 | TBXAS1 (0.62) | TBXAS1CYP19A1 | |
| SCHEMBL10553754 | 0.81 | TBXAS1 (0.62) | TBXAS1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150892-B1 | SUBSTITUTED ALKYLIDENE IMIDAZOLES | G.D. Searle & Co. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4837333-A | SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE ENZYME | G. D. SEARLE & CO. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0150892-A2 | Substituted alkylidene imidazoles | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |