Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826187 | 0.88 | KMT2A (0.36) | CYP1A2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9827162 | 0.79 | KDM4E (0.41) | CYP1A2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9434157 | 0.75 | KDM4E (0.44) | KMT2AALDH1A1KDM4ETP53CYP2C9 | |
| SCHEMBL28353288 | 0.70 | CYP1A2 (0.50) | CYP1A2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9826180 | 0.69 | ALDH1A1 (0.40) | KMT2AALDH1A1MEN1KDM4ETP53 | |
| SCHEMBL9434171 | 0.66 | KMT2A (0.40) | KMT2AALDH1A1MEN1KDM4ETP53 | |
| SCHEMBL9988559 | 0.64 | KMT2A (0.50) | KMT2AALDH1A1RXRARXRB | |
| SCHEMBL1458531 | 0.64 | KMT2A (0.50) | KMT2AALDH1A1KDM4ERXRARXRB | |
| SCHEMBL1356879 | 0.64 | CYP1A2 (0.55) | CYP1A2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL28353415 | 0.64 | CYP1A2 (0.42) | CYP1A2KMT2AALDH1A1MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |