Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.71 |
| ▸ | CTSK | P43235 | 11/20 | 0.71 |
| ▸ | CTSB | P07858 | 4/20 | 0.71 |
| ▸ | CTSL | P07711 | 2/20 | 0.71 |
| ▸ | AKT1 | P31749 | 1/20 | 0.62 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11948883 | 0.89 | CTSS (0.72) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL13128261 | 0.88 | CTSS (0.68) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL2440946 | 0.86 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL10040933 | 0.86 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL21010315 | 0.86 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL16510451 | 0.85 | CTSS (0.64) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3383006 | 0.85 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7724300 | 0.85 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL12204485 | 0.85 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL2793925 | 0.84 | CTSS (0.76) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |