Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825744 | 0.85 | FGFR1 (0.45) | GAAFGFR1PKMXDHROCK2 | |
| SCHEMBL9826991 | 0.80 | FGFR1 (0.45) | GAAFGFR1PKMXDHROCK2 | |
| SCHEMBL30716457 | 0.77 | GAA (0.51) | GAAFGFR1XDHROCK2PIM1 | |
| SCHEMBL1079479 | 0.74 | PIK3R2 (0.51) | GAAPKMNOTUMPARP1HPGD | |
| SCHEMBL28682936 | 0.74 | HTT (0.58) | HPGDGABRA2GABRB2ALDH1A1KDM4E | |
| SCHEMBL946120 | 0.74 | PARP1 (0.51) | FGFR1ROCK2PIM1PIM3PARP1 | |
| SCHEMBL29829977 | 0.73 | FGFR1 (0.57) | FGFR1XDHROCK2PIM1PIM3 | |
| SCHEMBL9826004 | 0.72 | HCAR1 (0.49) | GAAFGFR1PKMXDHHCAR1 | |
| SCHEMBL23675166 | 0.71 | FGFR1 (0.76) | FGFR1ROCK2PIM1PIM3HPGD | |
| SCHEMBL9464501 | 0.70 | FGFR1 (0.47) | FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282502-B1 | IMIDAZOLE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-05-15 | — | — | EP | claimed |
| US-4952698-A | Imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | claimed |
| US-4952698-A | Imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |